Why now is the right time to map the brain by recording its billions of neurons one-at-a-time
April 2, 2013 President Obama announced that he was requesting 100 million dollars of the US research budget be devoted to the Brain Activity Map project. This project also goes by the name of BRAIN. That is short for Brain Research through Advancing Innovative Neurotechnologies. BRAIN is probably a better title than the original for this project – BAM.
The ambitious goal of BRAIN is to create a map of the brain and to understand brain circuit function. Scientists hope to complete this research over the next 20 years. When it is finished, scientists project it will be possible to record and manipulate with precision the activity of nerve circuits, nerve networks, and maybe even whole brains.
Most of the effort in this project will be devoted to building the new tools necessary to monitor neurons one-at-a-time. It is hoped that BRAIN will become a cross scientific discipline, and a collaborative effort among multinational, private, government, and industry participants.
By September, 2013 the U.S. National Institutes of Health (NIH) completed its first attempt at creating its plan for its role in BRAIN. Their vision is to combine nine approaches into an integrated science of cells and circuits that describe brain behavior.
The nine research areas were identified as high priority in the committee’s interim report.
#1. Generate a Census of Cell Types. Characterize all of the various types of neurons present in the brain.
#2. Create Structural Maps of the Brain. Anatomic reconstruction of neural circuits at all levels.
#3. Develop New Large-Scale Network Recording Capabilities. Recording neuronal activity from complete neural networks over long periods in all areas of the brain.
#4. Develop A Suite of Tools for Circuit Manipulation. Directly activate and inhibit populations of neurons.
#5. Link Neuronal Activity to Behavior. Increase understanding of how neuronal activity underlies cognition and behavior.
#6. Integrate Theory, Modeling, Statistics, and Computation with Experimentation. New methods of data analysis and interpretation.
#7. Delineate Mechanisms Underlying Human Imaging Technologies. Develop a better understanding of cellular mechanisms underlying clinically measured brain images.
#8. Create Mechanisms to Enable Collection of Human Data. Maximize the collection of clinical imaging data for analysis of the mechanisms of brain disorders.
#9. Disseminate Knowledge and Training. Course modules for educating non-neuroscientists in computational neuroscience, statistics, imaging, electrophysiology, and optogenetics.
The refined and final report of this NIH committee is expected in June, 2014. You may notice when reading these goals that the project is indeed focused upon neurons. There is no mention of the other 90% of the cells in the brain that modify the activity of neuronal circuitry.
An executive summary of the NIH interim committee’s report can be found by clicking here.
Many introductory – and advanced – courses in physiology and in anatomy spend little or no time teaching the nervous system. It is often the last system to be included in the teaching schedule. The hope sometimes is that the semester will expire before it is time to learn all that confusing stuff. Now may be the time to reverse that trend and begin physiology courses by teaching the central nervous system.
Other posts on this site are designed to bring you up-to-date on what we already know about the human brain. My plan is help you to be ready to evaluate the meaning of data produced by the BRAIN project as it is acquired.
Having the fundamental concepts of neurophysiology firmly in your mind will place you in a superior position to deal with the ethical dilemmas that knowledge produced by BRAIN will surely bring with it. Now is the time for you to get started with your study of the human brain and nervous system.
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Margaret Thompson Reece PhD, physiologist, former Senior Scientist and Laboratory Director at academic medical centers in California, New York and Massachusetts and CSO at Serometrix LLC is now CEO at Reece Biomedical Consulting LLC.
Dr. Reece is passionate about helping students, online and in person, pursue careers in life sciences. Her books “Physiology: Custom-Designed Chemistry” (2012), “Inside the Closed World of the Brain” (2015) and the workbook (2017) companion to her online course “30-Day Challenge: Craft Your Plan for Learning Physiology” are written for those new to life science. More about her books can be found at amazon/author/margaretreece.
Dr. Reece offers a free 30 minute “how-to-get-started” phone conference to students struggling with human anatomy and physiology. Appointments are scheduled by email at DrReece@MedicalScienceNavigator.com.by